Air Delivery of Super-Cooled COVID-19 Vaccines

There are several potential COVID-19 vaccines that may soon be available for widespread distribution. In particular, the United Kingdom has recently approved Pfizer’s vaccine, and the U.S. Food and Drug Administration is considering extending Emergency Use Authorization to the Pfizer and Moderna vaccines.

That is certainly promising news, but storage, transportation, and delivery of these potentially game-changing vaccines will be quite challenging, with the CEO of the International Air Transport Association describing the distribution of COVID-19 vaccines as “the largest and most complex logistical exercise ever” undertaken.

It is not just the huge numbers (literally, in the billions of doses) and vast geographic scope (worldwide, requiring delivery to every country on the planet) that make the COVID-19 vaccine distribution task so daunting, but both the Pfizer and Moderna vaccines must be stored and transported in strict climate-controlled environments (reportedly, at some -70 degrees Celsius for Pfizer, and -20 degrees Celsius for Moderna) as integral parts of the vaccines’ “cold chains.”

COVID-19 Vaccine Cold Chain

The U.S. Centers for Disease Control (the “CDC”) describes a cold chain as a temperature-controlled supply chain that includes all vaccine-related equipment and procedures. The vaccine cold chain begins with a cold storage unit at the vaccine manufacturing plant, extends to the transport and delivery of the vaccine (including proper storage at the provider facility), and ends with the administration of the vaccine to the patient. A breakdown in protocols anywhere along the cold chain could reduce the effectiveness of, or even destroy, a vaccine.

Given the extreme cold temperatures required within their cold chains by the Pfizer and Moderna vaccines (and, perhaps, other COVID-19 vaccines that may now be under development by other firms), various companies within the vaccine delivery network (including temperature-controlled container manufacturers, logistics specialists, storage facility operators, commercial airlines, and dry ice producers) have been hard at work for months to meet the challenges associated with safely storing and transporting billions of vaccine doses once, as now appears to be at hand, they finally become available for international distribution.

Creating Super-Cold Environments

Dry ice, which is the common name for solid (i.e., frozen) carbon dioxide, is often used in cold chains to maintain the very cold temperatures required to keep certain vaccines viable. At a temperature of approximately -78.5 degrees Celsius (equating to -109.3 degrees Fahrenheit), dry ice is significantly colder than frozen water (that is, conventional ice), making it ideal for transport and storage of those vaccines which require an extremely cold temperature environment.

Safety precautions are critical when shippers use dry ice in the transportation and storage of vaccines. Unlike conventional ice, dry ice does not melt into a liquid. Instead, dry ice “sublimates” (changes from a solid to a gas state), turning into carbon dioxide gas. In poorly ventilated, confined spaces, such as storage rooms, railway cars, trucks, and cargo holds in airplanes, carbon dioxide can build up, creating a potentially serious health risk to transportation workers, including ground and flight crews.

Certain vaccine manufacturers may elect to ship their vaccines in multi-layered, storage canisters chilled with liquid nitrogen, rather than dry ice. We note that the potential health risks associated with nitrogen leaks are similar to those that may be caused by dry ice sublimation.

Oxygen Deficiency Risks Associated with Super-Cooled Environments

Carbon dioxide (as is nitrogen) is an oxygen-depleting gas that is both odorless and colorless. As such, absent appropriate monitoring, personnel working with the transportation of COVID-19 and other vaccines kept frozen with dry ice or liquid nitrogen likely would be unable to detect if dry ice were to sublimate (causing CO2 levels to rise), or if there were a nitrogen gas leak, and an associated decrease in oxygen.

According to the Occupational Safety and Health Administration (OSHA), an environment in which oxygen levels fall below 19.5 percent is considered an oxygen-deficient atmosphere and should be treated as immediately dangerous to health or life. When there is not enough oxygen in the air, persons working in the affected area may become disoriented, lose consciousness, or even suffocate due to the lack of sufficient oxygen.

FAA Guidance/Increased Air Shipment Capacity/Risk Mitigation

On May 22, 2009, the U.S. Federal Aviation Administration (the “FAA”) issued Advisory Circular No. 91-76A to specifically address the risks associated with the sublimation of dry ice aboard aircraft and, historically, the FAA has permitted even widebody aircraft to carry only relatively small amounts (typically not exceeding 1-1.5 tons per flight) of dry ice in refrigerated and insulated containers.

However, The Wall Street Journal (the “WSJ”) reported on November 29, 2020, that, in order to maintain the ultra-cold temperatures required by Pfizer’s COVID-19 vaccine, United Airlines has recently sought, and obtained, FAA approval to carry up to 15, 000 pounds (7.5 tons) of dry ice per flight. In a December 2, 2020 interview with CNN, Josh Earnest, Chief Communications Officer with United Airlines, noted that the FAA approval will allow United to ship as many as 1.1 million doses of COVID-19 vaccines on each flight of its commercial 777 airplanes.

Notwithstanding the FAA’s relaxation of dry ice weight limits to permit United Airlines to help bring the COVID-19 pandemic under control, it remains focused on risks associated with air shipments of dry ice. In its November 29, 2020 reporting, the WSJ noted that “regulators restrict the amount of dry ice that can be carried on passenger jets because they typically lack the equipment to monitor and mitigate any leaked carbon dioxide.”

Fortunately, by utilizing a top-quality oxygen-deficiency monitor, vaccine storage and transportation personnel, including flight crews, can safely track levels of oxygen and detect (and react to) potentially dangerous low oxygen levels, whether caused by dry ice sublimation or a nitrogen gas leak.

PureAire Monitoring Systems, Inc.

PureAire Monitoring Systems’ Oxygen Deficiency Monitor offers thorough air monitoring, with no time-consuming maintenance or calibration required. A screen displays current oxygen levels, for at-a-glance reading by crew members, who derive peace of mind from the Monitor’s presence and reliable performance.

Built with zirconium oxide sensor cells, to ensure longevity, the Monitor can last, trouble-free for 10 years in normal working conditions.

Our Oxygen Deficiency Monitor does not rely on the partial pressure of oxygen to operate, meaning that the Monitor is not affected by the changing pressure inside an aircraft due to altitude changes. In the event that dry ice begins to sublimate (causing carbon dioxide levels to rise), or if there is a nitrogen leak, and oxygen decreases to unsafe levels, PureAire’s Monitor will set off an alarm, complete with horns and flashing lights, alerting flight personnel to take corrective action.

For over 20 years, PureAire Monitoring Systems has been an industry leader in manufacturing long-lasting, accurate, and reliable Oxygen Deficiency Monitors. We have dedicated ourselves to ensuring the safety and satisfaction of our clients, many of which have very sophisticated operating requirements. We are proud to note that NASA’s SOFIA-Stratospheric Observatory for Infrared Astronomy--a Boeing 747SP aircraft modified to carry a 2.7 meter (106 inch) reflecting telescope--carries onboard a PureAire Oxygen Deficiency Monitor.

What are Oxygen Deficiency Monitors?

What is an Oxygen Deficient Environment?

The Occupational Safety and Health Administration (OSHA) defines an environment in which oxygen levels fall below 19.5 percent as an oxygen-deficient atmosphere, which should be treated as immediately dangerous to health or life. When there is not enough oxygen in the air, persons within the affected area may become disoriented, lose consciousness, or even suffocate due to the lack of sufficient oxygen.

An oxygen-deficient environment may be created when oxygen is displaced by inert gases, such as nitrogen, helium, argon, or carbon dioxide. Therefore, manufacturers and other organizations utilizing inert gases in their operations need to successfully navigate complex working environments in which high concentrations of such gases may be critical to production procedures, but where the risks of oxygen deficiency may pose a potential safety hazard for their employees.

Fortunately, by utilizing a top-quality oxygen deficiency monitor, facility managers can maintain stringent processing requirements, as well as protect the health and safety of their personnel.

What is an Oxygen Deficiency Monitor?

An oxygen deficiency monitor is a device that measures oxygen levels in a particular area. By continuously tracking oxygen levels, oxygen deficiency monitors are designed to detect gas leaks from oxygen-depleting gases before employee health is jeopardized.

A number of gases, including nitrogen, helium, carbon dioxide, and argon, among others, are odorless, colorless, oxygen-depleting gases. As such, unless they are using a reliable oxygen deficiency monitor, personnel would likely be unable to detect a gas leak should one occur in a gas cylinder or line.

Which Industries Should Use Oxygen Deficiency Monitors?

Oxygen deficiency monitors contribute to safe working environments in any scientific or industrial application utilizing oxygen-depleting gases and, therefore, requiring continuous monitoring of oxygen levels. For instance:

• The medical industry uses inert gases for a variety of purposes, including MRI facilities, performing cryosurgery, in-vitro fertilization, and cryostorage facilities, and for blood and tissue preservation, while laboratories typically use compressed gases including argon, nitrogen, and carbon dioxide.
• Pharmaceutical manufacturers depend upon gases such as nitrogen and carbon dioxide to maintain sterile environments throughout the drug manufacturing and packaging processes.
• The food and beverage industries rely on carbon dioxide and nitrogen gas for a range of uses. By way of example, carbon dioxide carbonates beverages in bars, fast-food establishments, and restaurants, and it is a critical component in the productions of soft drinks and beer. Nitrogen gas is important in food preservation processes, where it is used to remove oxygen from the manufacturing environment, extend product shelf life, and decrease the likelihood of spoilage.
• Semiconductor fabricators and foundries must closely monitor process gas levels, as an improper amount of gas can ruin the quality and integrity of the components and devices being manufactured.

The foregoing bullet points highlight just a few of the industries that need oxygen deficiency monitors as part of their daily operations. Others include aerospace, cryotherapy, additive manufacturing, research and development, alternative fuel, waste management, and the oil and gas sectors.

PureAire Oxygen Deficiency Monitors

PureAire Monitoring Systems’ line of oxygen deficiency monitors offer thorough air monitoring, with no time-consuming maintenance or calibration required. Our monitor continuously tracks oxygen levels and, in the event of a gas leak and a drop in oxygen to an OSHA action level, will set off an alarm, complete with horns and flashing lights, alerting employees to evacuate the affected area.

The monitor will remain accurate at temperatures as low as -40C. PureAire’s durable, non-depleting, long-life zirconium oxide sensor will last for 10+ years in a normal environment without needing to be replaced.

Where Should Oxygen Deficiency  Monitors Be Installed?

Oxygen deficiency monitors should be installed 3 to 5 feet away from a gas cylinder or gas line, and in any location where there is a risk of gas leaks that may cause a drop in oxygen to an unsafe level.  So that employees can see the monitors and verify their performance, the monitors should typically be mounted 3 to 5 feet off the ground.

There are many other configurations for mounting. For instance, PureAire oxygen deficiency monitors can sample oxygen levels from up to 100 feet away using ¼  inch tubing, or be installed within a glovebox, freezer, gas line, sealed chamber, or even below ground level. PureAire oxygen deficiency sensors can be mounted directly in vacuum chambers with the use of a KF25 vacuum fitting.

How Many Oxygen Deficiency Monitors Do I need?

To ensure safety, PureAire generally recommends that one monitor be installed for approximately every 400 square feet of your facility’s space. However, since cryogenic gases, such as argon, helium, and nitrogen, are unpredictable, we encourage you to contact PureAire for additional guidance specific to your needs.

Don't Throw Away Your Shot...the Cold Truth About Vaccine Handling and Storage

 

In modern times, vaccines have been widely used to keep people healthy by protecting them from serious illnesses and diseases. Worldwide, vaccines annually prevent millions of deaths, and their utilization is responsible, in many parts of the globe, for the nearly total eradication of numerous diseases, including polio, measles, and smallpox.

According to the U.S. Centers for Disease Control (the "CDC"), a vaccine for a specific disease stimulates an individual's immune system, causing it to produce antibodies to counteract the antigens associated with the disease in question, just as one's immune system would do if one were actually exposed to the disease. The concept is that, after getting vaccinated, the inoculated patient develops immunity to the disease without first having to contract it. Unlike medicines, which are used to treat or cure diseases, vaccines are intended to prevent them.

Handling and Storage of Vaccines

Developing a vaccine can take years before it is deemed safe for human use and, thereafter, manufactured and made available for widespread distribution and inoculation. Throughout the manufacturing and  distribution process, and up to the time of administration, a vaccine must be kept in strict climate-controlled environments, collectively referred to as the "cold chain." The CDC describes a cold chain as a temperature-controlled supply chain that includes all vaccine-related equipment and procedures. The vaccine cold chain begins with a cold storage unit at the vaccine manufacturing plant, extends to the transport and delivery of the vaccine (including proper storage at the provider facility), and ends with the administration of the vaccine to the patient. A breakdown in protocols anywhere along the cold chain could reduce the effectiveness of, or even destroy, a vaccine.

According to FedEx, while most vaccines have traditionally been transported in a cold temperature range of 2 degrees Celsius to 8 degrees Celsius, certain vaccine manufacturers and pharmaceutical firms require a much lower temperature range within the cold chain associated with specific vaccine products.

Dry ice, which is the common name for solid (i.e., frozen) carbon dioxide, is often used in cold chains to maintain the very cold temperatures required to keep certain vaccines viable. At a temperature of approximately -78.5 degrees Celsius (equating to  -109.3 degrees Fahrenheit), dry ice is significantly colder than frozen water (that is, conventional ice), making it ideal for transport and storage of those vaccines requiring an extremely cold temperature environment.

Safely Tracking Carbon Dioxide Levels When Working with Dry Ice

Safety precautions are critical when shippers use dry ice in the transportation and storage of vaccines. Unlike conventional ice, dry ice does not melt into a liquid. Instead,  dry ice "sublimates" (changes from a solid to a gas state), turning into carbon dioxide gas. In small, poorly ventilated spaces, such as storage rooms and closets, cargo vans, trucks, and airplanes, carbon dioxide can build up, creating a potentially serious health risk.

Carbon dioxide is an oxygen-depleting gas that is both odorless and colorless. As such, absent appropriate monitoring, workers involved with the transportation and/or storage of products frozen with dry ice likely would be unable to detect if dry ice were to begin to sublimate, with carbon dioxide gas levels possibly rising to unsafe levels. When there is not enough oxygen in the air, persons working in the affected area may become disoriented, lose consciousness, or even suffocate due to the lack of oxygen

Fortunately, by utilizing a top-quality oxygen monitor, also known as an oxygen deficiency monitor, vaccine transportation storage personnel can track oxygen levels and detect (and react to) dangerous carbon dioxide levels before employee health is jeopardized.

PureAire Dual Oxygen/Carbon Dioxide Monitor

PureAire Monitoring Systems' Dual Oxygen/Carbon Dioxide Monitor offers thorough air monitoring, with no time-consuming maintenance or calibration required.  A screen displays current oxygen and carbon dioxide levels, for at-a-glance reading by employees, who derive peace of mind from the Monitor's presence and reliable performance.

In the event that dry ice begins to sublimate, causing carbon dioxide levels to rise, and oxygen to decrease to unsafe levels, PureAire's Monitor will set off an alarm, complete with horns and flashing lights, alerting personnel to evacuate the area.

Our Dual Oxygen/Carbon Dioxide Monitor is well-suited for industries where dry ice is used, such as in the handling, transportation, and storage of life-saving vaccines. The Monitor includes both a non-depleting, zirconium oxide sensor cell, to monitor oxygen levels, and a non-dispersive infrared (NDIR) sensor cell, to monitor carbon dioxide levels. Known for their dependability, PureAire's O2/CO2 Monitors can last, trouble-free, for over 10 years under normal operating conditions.

Brewers Safely Capture and Reuse Carbon Dioxide

 

Brewing beer produces carbon dioxide (CO₂), especially during fermentation (the process by which yeast converts sugars into alcohol). Estimates are that fermentation yields three times as much carbon dioxide as is actually needed to produce (including brewing, canning, and bottling) each batch of beer, with up to 15 grams of CO₂ generated per pint of beer brewed. According to the British Beer & Pub Association, over 8 billion pints of beer were consumed in the United Kingdom alone in 2019, contributing to the production of a whole lot of carbon dioxide.

While large, global breweries, with their vast financial resources, have been recapturing and reusing carbon dioxide for a number of years, most craft brewers have considered carbon recapture technology to be prohibitively expensive. They have treated excess CO₂ as waste, and vented it into the atmosphere, though that practice may make little sense, either economically or environmentally since, in order to produce subsequent batches, brewers must then turn around and purchase carbon dioxide to carbonate the beer, purge beer tanks and lines of oxygen, and to transfer the beer from tanks to bottles or cans.

And carbon dioxide purchase is a recurring line-item expense that eats into craft brewers’ profit margins.

Capturing and Reusing Carbon Dioxide

The good news is that recent technological innovations, driven in large part by companies working with NASA on space exploration and investigation, have led entrepreneurs to an awareness that CO₂ recapture may in fact now be seen as a relatively affordable, and certainly environmentally friendly, option for craft breweries. The technology involves capturing the CO₂ that has accumulated during fermentation and purifying the gas to make it suitable for reuse and/or sale.

The Washington Post has reported that Texas-based Earthly Labs has created a product called “CiCi” (for “carbon capture”), a refrigerator-sized unit that enables brewers to trap and reuse accumulated carbon dioxide. Captured CO₂ is piped from the fermentation tanks to a “dryer” to separate water from CO₂gas. The gas is next purified and chilled to a liquid for ease of storage and subsequent use.

Brewers can reuse their stored carbon dioxide to carbonate new batches of beer, as well as in the canning and bottling processes for the new beer. Craft Brewing Business, a trade website dedicated to the business of commercial craft brewing, reports that breweries can reduce monthly carbon dioxide expenses by 50 percent or more, and CO₂ emissions by up to 50%, via carbon capture technology.

Breweries that capture more CO₂ than they can use, may elect to sell the surplus to other breweries, bars, restaurants, and any other businesses that also use carbon dioxide. For instance, the State of Colorado, Earthly Labs, the Denver Beer Co., and The Clinic announced in early 2020 a pilot program in which Denver Beer Co. would sell its surplus CO₂ to The Clinic, a medical and recreational cannabis dispensary, which would then pump the carbon dioxide inside its grow rooms to stimulate and enrich plant growth.

Oxygen Monitors Can Mitigate Unseen Dangers of Carbon Dioxide

Brewers and others working around carbon dioxide need to be aware of the potential risks associated with CO₂. Carbon dioxide is an odorless and colorless oxygen-depleting gas. Since it deprives the air of oxygen, CO₂ use presents a potential health hazard for brewery personnel.

According to the Occupational Safety and Health Administration (OSHA), an environment in which oxygen levels fall below 19.5 percent is considered an oxygen-deficient atmosphere and should be treated as immediately dangerous to health or life. When there is not enough oxygen in the air, persons working in the affected area may become disoriented, lose consciousness, or even suffocate due to the lack of sufficient oxygen. Because CO₂ is devoid of odor and color, individuals working around it might well, in the absence of appropriate monitoring equipment, be unaware that a risk situation has developed.

As such, The National Fire Protection Association recommends that gas monitoring equipment be placed in storage areas or any place where carbon dioxide is used or stored.

PureAire Dual O₂/CO₂ Monitors

\

PureAire Monitoring Systems’ Dual Oxygen/Carbon Dioxide Monitor offers thorough air monitoring, with no time-consuming maintenance or calibration required. A screen displays current oxygen and carbon dioxide levels for at-a-glance reading by brewery employees, who derive peace of mind from the Monitor’s presence and reliable performance.

In the event of a carbon dioxide leak, and a decrease in oxygen to an unsafe level, PureAire’s Monitor will set off an alarm, complete with horns and flashing lights, alerting brewery personnel to evacuate the area.

PureAire’s Dual Oxygen/Carbon Dioxide Monitor is well-suited for facilities where carbon dioxide is used, such as breweries, bars, and restaurants. Our Dual O₂/CO₂ monitor includes both a non-depleting, zirconium oxide sensor cell, to monitor oxygen levels, and a non-dispersive infrared (NDIR) sensor cell, to monitor carbon dioxide levels. PureAire’s O₂/CO₂ monitors can last, trouble-free, for over 10 years under normal operating conditions.

Saving money, reducing greenhouse gas emissions, and ensuring employee safety...that is certainly something to which we can all raise a glass.

Image is Everything: MRI and Helium Safety

 

MRI

Magnetic resonance imaging (MRI) is a diagnostic procedure that uses a combination of a very large magnet, radio waves, and a computer to produce detailed, cross-sectional, and three-dimensional images of organs and structures within the body.

An MRI scan is a valuable diagnostic tool that can show injuries or other anomalies that cannot be seen in a CT scan or X-ray.  For instance, soft tissue injuries, such as,strains, sprains, contusions, tendonitis, and bursitis can all be observed via MRI.

Moreover, according to the Mayo Clinic, MRI can also be used to diagnose a variety of brain-related and nervous system disorders, including strokes, aneurysms, multiple sclerosis, eye and inner ear problems, and spinal cord injuries. MRI is widely used in research on brain structures and functions.

How MRI Works

MRI scanning machines vary in size, shape, and degree of openness but the typical MRI machine resembles a tube (encompassing a very large magnet) with a table in the middle, which enables the patient to lie down and slide into the magnetic field created inside the machine. The magnet itself is comprised of multiple coils of connective wire through which a current is passed to generate a magnetic field. To achieve the high field strengths required for most clinical needs, the magnet is cooled with liquid helium to -452 degrees Fahrenheit (-270 Celsius). The super cold temperature applied to the magnet provides for “superconductivity”, meaning that current can pass through the magnet’s coils without electrical resistance, producing the type of strong magnetic field necessary to produce detailed images.

To ensure accurate imaging, and to preserve the integrity of the MRI scanning machine, the liquid helium must be kept extremely cold when the scanner is in operation. If the temperature of the liquid helium were to rise above the very cold levels required for superconductivity, the helium might vaporize and,with the dissipation of the liquid helium’s super-cooling properties,  the machine’s magnet could overheat, potentially causing irreparable damage to the MRI machine.

Oxygen Monitors Can Detect Helium Leaks

Helium is an odorless, colorless, oxygen-depleting gas that can rapidly displace oxygen in the air to levels below what is needed to for humans to breathe. Excess exposure to helium can cause dizziness, nausea, and loss of consciousness, and could even result in death within seconds of exposure. Because liquid helium is devoid of color and odor, MRI personnel would, absent appropriate oxygen monitoring, likely be unaware that a potentially dangerous helium leak has occurred. As such, the National Institutes of Health’s Design Requirements Manual recommends that oxygen monitors be installed in MRI treatment areas.

Proper oxygen monitoring equipment should be placed in MRI rooms, as well as in storage rooms, and in any other site where helium gas may accumulate. The monitoring equipment should include visual and audible alarms that would be activated in the event of helium leaks and a decrease in oxygen levels.

PureAire Oxygen Deficiency Monitors

PureAire Monitoring Systems’ Sample Draw Oxygen Deficiency Monitor continuously tracks levels of oxygen and will detect helium leaks before MRI machines are damaged and the health of employees and patients is put at risk.

The Monitor’s built-in pump samples oxygen from up to 100 feet away,making it ideal for use in MRI facilities, because the metal components within the Monitor are outside the imaging area and, therefore, will not interfere with the magnets that are the heart of MRI scanning machines.

PureAire’s durable, non-depleting, zirconium oxide sensor can last 10+ years in a normal environment, without needing to be replaced.

In the event of a helium gas leak, and a decrease in oxygen to an unsafe, OSHA action level, the Sample Draw Oxygen Monitor will set off an alarm, complete with horns and flashing lights, alerting staff and patients to evacuate the area. Additionally, the same alarm will alert personnel to turn off the MRI scanner in order to prevent the magnet overheating that could result in possible damage to the machine.

PureAire’s Sample Draw Oxygen Deficiency Monitor has an easy to read screen, which displays current oxygen levels, for at-a-glance observation by MRI employees, who derive peace of mind from the Monitor’s presence and reliability.

What Are Hot Melt Adhesives? Why Are They Used and What Is the Importance Of Nitrogen Gas?

 Hot Melt Adhesives and Available Types Used in Industrial Manufacturing

Industrial hot melt adhesives are polymer-based thermoplastic resins that, when melted, are used to bond materials together. Hot melt adhesives are comprised of one or more base polymers combined with tackifiers (which provide stickiness to the adhesive), plasticizers (to provide greater flexibility), and antioxidants (for protection against degradation) to allow for stability, adhesion, and flexibility.

Industrial hot melt is available in a variety of forms, including granular or powder hot melt blocks, pellets, bags, cakes, drums, and pillows. These materials are solid at room temperature, and then heated, melted, and dispensed for a variety of industrial applications.  As the adhesive returns to room temperature, a strong bond is created, adhering the manufacturing components together.

Hot melt can be dispensed as a liquid or, by introducing an inert gas (such as nitrogen) to the hot melt, as a foam.

Industrial Hot Melt Applications

In either liquid or foam form, hot melt adhesive is used across a wide variety of industries including  aerospace; automotive; product assembly; furniture making, cabinetry, and upholstery; product packaging; book binding; and non-woven sanitary hygiene products.

Aerospace and automobile manufacturers utilize hot melt adhesives for potting electronics (a process used to protect sensitive components from impact or vibration), as well as sealing rivets, seams, and joints. Additionally, hot melt foam is used in airplanes and cars as insulation around doors and windows to reduce vibrations and noise, as well as in seat assembly.

The pages in books and magazines are kept securely bound together using HMAs. The packaging industry depends on a strong adhesive bond to keep the flaps of corrugated boxes and cartons securely closed.

Non-woven personal hygiene products are manufactured by utilizing hot melt adhesives throughout the manufacturing process, including adhering the elastic strands in the leg openings and waistbands, bonding the fabric layers together to secure and stabilize the wetness core, and affixing the fastening tapes to the waistband.

Charring

Charring is akey concern when working with hot melt adhesives, as char (degraded adhesives that have oxidized, hardened into a gel, and been blackened and burned) can negatively affect the adhesives, cause equipment failure, and lead to a shut-down in production.

Key causes of charring include overheating (typically as a result of either using a temperature that is too high for a particular hotmelt, excessive heating times, or incorrect melt tank size); oxidation (exposing the adhesives to too much oxygen), and contamination (from dirt, dust and other materials that fall into the hotmelt and burn).

Once formed, the char can break off into pieces that may clog filters and stop up spray and bead nozzles. The pieces of char can work their way onto the materials to be bonded, leaving marks, streaks, and uneven surfaces. Eventually, bits of char may get into hoses and pumps, breaking seals and scoring and damaging hoses and pump walls.

Why Nitrogen is Used for Hot Melt Adhesive

To reduce potential damage from charring, hotmelt operators may elect to blanket the adhesives with nitrogen (N2) in a process by which nitrogen, an oxygen depleting gas, is piped into the space between the hotmelt adhesive and the top of the hopper or melt tank. The nitrogen blanket protects the adhesive by creating a barrier against falling debris, and it also removes oxygen and moisture which may cause the hotmelt to oxidize and form char .

Oxygen Monitors Improves Quality Control and Helps Protect Employees

To preserve the integrity of the hot melt while blanketing with nitrogen, employees must maintain proper oxygen levels within hoppers or melt tanks, as too much oxygen can cause oxidation. Proper oxygen monitoring equipment should be placed inside melt tanks to measure and control oxygen levels.  A nitrogen leak could lead to failure of the nitrogen blanket, which could compromise the integrity of the adhesives.

Moreover, wherever nitrogen is used, the possibility of nitrogen leaks poses potential risks to humans. Since nitrogen displaces oxygen, a leak could deprive the air of oxygen, thereby creating a possible health hazard for personnel. When there is not enough oxygen in the air, persons working in the area can become disoriented, lose consciousness, or even suffocate due to the lack of oxygen. Since nitrogen lacks color and odor, there is no way, absent appropriate monitoring, for employees to detect a leak.

Best practice calls for oxygen deficiency monitors to be installed anywhere there is a risk of gas leaks. As such, oxygen monitors should be placed wherever nitrogen is stored, and in all areas where nitrogen is used.

PureAire O2 Deficiency Monitors

PureAire Monitoring Systems’ line of Oxygen Deficiency Monitors and Water Resistant Sample Draw Oxygen Monitors continuously track levels of oxygen and will alert hotmelt personnel to nitrogen leaks before employees’ health is put at risk.  In the event of a nitrogen gas leak, and a decrease in oxygen to an unsafe level, the monitor will set off an alarm, complete with horns and flashing lights, alerting employees to evacuate the area.

PureAire’s Water Resistant Sample Draw Oxygen Monitor is a self-contained oxygen deficiency system that is suitable for remote sampling of oxygen levels in confined spaces, hotmelt tanks, and other locations where remote oxygen monitoring is required. The built-in pump samples oxygen levels from up to 100 feet away.

PureAire oxygen monitors measure oxygen 24/7, with no time-consuming maintenance or calibration required. Built with zirconium oxide sensor cells to ensure longevity, PureAire’s O2 monitors can last, trouble-free, for over 10 years under normal operating conditions.Each PureAire O2 monitor has an easy to read screen, which displays current oxygen levels, for at-a-glance readings by hotmelt manufacturers, who derive peace of mind from the monitor’s presence and reliability.

Pharmaceutical Companies Rely on Nitrogen

Pharmaceutical firms research, develop, and manufacture over-the-counter and prescription drugs and medicines. Usage of these drugs includes, but is not limited to, vaccinations, treatment for chronic conditions, and pain management.

To protect the health and well-being of the public, the pharmaceutical industry is one of the most highly regulated industries. For instance, in the United States, the Food and Drug Administration (FDA) carefully monitors pharmaceutical companies to ensure they are complying with the FDA’s Current Good Manufacturing Practice regulations. These regulations contain requirements for the methods, facilities, and controls used in manufacturing, processing, and packaging of a drug product.  The regulations are intended to ensure that a product is safe for use, and that it contains the ingredients and strengths it claims to have.

Pharmaceutical Manufacturers Rely on Nitrogen

Pharmaceutical manufacturers rely on nitrogen(N2) (an abundant, inert gas which makes up 78% of the air we breathe) for a wide range of uses, including everything from mixing raw materials, to cryogenic grinding (a process using liquid nitrogen to create ultra-fine, uniform particles), to purging oxygen from packaging.

A sterile environment is critical throughout the drug manufacturing and packaging processes. Nitrogen is used to remove oxygen (O2), moisture, and other possible contaminants,in order to create and maintain a sterile environment for production and packaging.

Nitrogen blanketing is the process by which pharmaceutical manufacturers create an inert, non-reactive, environment for safely mixing chemical compounds. Blanketing with nitrogen safeguards against corrosion and oxidation, and prevents possible volatile reactions that might occur if O2 were present, as  some medicinal compounds can be highly combustible when exposed to oxygen.

Oxygen and moisture are purged from packaging not only to maintain sterility but also to protect products during transport, and prolong the stability and shelf life of the packaged drugs.

Oxygen Monitors Can Reduce Risk in Pharmaceutical Manufacturing Facilities Utilizing Nitrogen

Nitrogen is an oxygen-depleting gas that is both odorless and colorless. As such, absent appropriate monitoring, workers would be unable to detect a nitrogen leak if one were to occur in a gas cylinder or line. When there is not enough oxygen in the air, persons working in the area can become disoriented, lose consciousness, or even suffocate due to the lack of oxygen.

Fortunately, by utilizing a top-quality oxygen monitor, also known as an oxygen deficiency monitor, pharmaceutical personnel can track oxygen levels and detect nitrogen leaks before an employee’s health is jeopardized.

PureAire Monitors

PureAire Monitoring Systems’ oxygen deficiency monitors continuously track levels of oxygen and will detect nitrogen leaks before the health of pharmaceutical personnel is put at risk. Built with zirconium oxide sensor cells to ensure longevity, PureAire’s O2 monitors can last, trouble-free, for over 10 years under normal operating conditions.  In the event of a nitrogen gas leak, and a decrease in oxygen to an unsafe level, the monitor will set off an alarm, complete with horns and flashing lights, alerting employees to evacuate the area.

Best practice calls for oxygen deficiency monitors to be installed anywhere there is a risk of gas leaks. The oxygen monitors should be placed wherever nitrogen is stored, and in all rooms and areas where nitrogen is used.

PureAire oxygen monitors measure oxygen 24/7, with no time-consuming maintenance or calibration required.

Each PureAire O2 monitor has an easy to read screen, which displays current oxygen levels, for at-a-glance readings by pharmaceutical manufacturing personnel, who derive peace of mind from the monitor’s presence and reliability.

Butane for THC and CBD Extraction Trend Requires Some Simple Steps to Stay Safe

On May 17^th, 2020, twelve firefighters were injured after an explosion occurred at a facility where butane is used for cannabis extraction. It is not yet known if butane was the cause of the explosion but, it was reported that, butane canisters where found in and around the building. The investigation is ongoing.

According to a Politico article, following an uptick in explosions in Colorado, fire officials there persuaded the National Fire Protection Association, which establishes a fire code for the whole country, to amend its rules to address hazards at facilities that grow and extract marijuana. The revised code requires any hazardous extraction process to be performed in a non-combustible room, in a building that contains no child or health care facilities. Staff must be trained on safe operation of the extraction equipment, and the extraction room must be equipped with a gas detection system and multiple fire extinguishing systems.

Extraction

Extraction is a process by which desired chemical compounds are extracted and separated from the cannabis plant. Extraction strips the plant of essential oils, including CBD, THC, and terpenes (aromatic oils that give cannabis plants their distinctive scents). The extracted oils can be utilized in vape pens, edibles, capsules, tinctures, and topical solutions.

Butane is one technique used to separate essential oils from the plant material. The use of butane for extraction is popular owing, in large part, to the relatively low overhead costs, efficiency (including the wide variety of products that can be created from a single extraction, without the need for further refinement), and high product quality associated with this technique. For instance, the low boiling point of butaneallow extractors to remove the desired compounds without risking evaporation of, or damage to, the delicate and heat-sensitive cannabinoids and terpenes. Moreover, the low boiling point makes it relatively easy to purge any residual butaneat the end of the extraction process, leaving behind only a relatively pure product.

Gas Detection Monitors Can Protect Extractors and Their Employees

While butane is important for extracting essential oils from cannabis plants use of this gas is not without risk, since extraction facility personnel and property are exposed to potential leaks from gas supply lines and storage containers. Butane is highly flammable and explosive gas as well.  Absent appropriate gas monitoring, an explosion can occur if butane vapors are ignited by a spark, heat, or open flame.

Proper gas detection equipment should be placed where the cannabis extraction process takes place, as well as in butane storage rooms, and in any other site where butanemay be expected to accumulate. The gas detection equipment should include the capacity to activate visual and audible alarms, stopping the flow of gas and turning on the ventilation system.

PureAire Monitors

PureAire Monitoring Systems has safety monitors to meet the needs of cannabis extractors using butane. Extractors utilizing butane rely on PureAire’s LEL, explosion-proof, combustible gas monitors. The monitor is housed in a NEMA 4 enclosure specifically designed to prevent an explosion. The durable, long-life LEL catalytic sensor will last 5+ years without needing to be replaced.

PureAire monitors feature an easy to read screen, which displays current oxygen levels for at-a-glance observation by employees, who derive peace of mind from the monitor’s presence and reliable performance. In the event of a gas leak, PureAire’s monitors will set off alarms, complete with horns and flashing lights, alerting personnel to evacuate the area. At the same time, the monitors can be programmed to turn off the flow of butaneand turn on the ventilation system.

In short, PureAire’s monitors enable cannabis extractors, in a cost-effective manner, to preserve both the quality of their products and the well-being of their employees.

 

Nitrogen Blanketing

Overview

Nitrogen (N2) blanketing is a process by which nitrogen is added to fill the headspace (the area between the fill line of a tank’s contents and the top of the storage vessel) to eliminate oxygen and moisture from storage tanks. Nitrogen is commonly used to blanket due to its extremely low reactivity with other substances, as well as its availability and relatively low cost. Other gases can also be used; however, some may be more reactive, and the costs higher,than nitrogen.

Why Blanket with Nitrogen?

Many industries, including oil, gas, and ethanol refineries, as well as chemical, pharmaceutical, and food processors, use nitrogen blanketing to prevent fires and explosions, and to preserve product quality.

Nitrogen blanketing can protect facilities from potentially catastrophic accidents when manufacturing combustibleand explosive chemicals, such as ethanol and other volatile materials, since removing oxygen eliminates the possibility of a fire and/or an explosion. Moreover, tank blanketing with nitrogen prevents oxygen, water, and other unwanted substances from coming into contact with the contents of the storage tanks, and/or causing undo wear of the tanks themselves, as oxygen and moisture inside storage tanks can cause evaporation and corrosion that may result in structural damage to the tanks.

Cooking oil processorstypically blanket with N2 to remove oxygen, which could otherwise oxidize the contents and negatively affect the tasteand,might decrease the shelf life of the oils.

Monitoring Mitigates Risks in Nitrogen Blanketing

Depending upon the needs of the facility and the type of tank, nitrogen is commonly supplied by one of the following methods: continuous purge (a constant flow of nitrogen), pressure control (N2 is added to maintain a set pressure within the tank), and concentration control.

The concentration control methodworks by using an oxygen detection monitor, in conjunction with a nitrogen generator, to continuously measure the level of oxygen inside the storage tank, and, if necessary,owing to elevated oxygen levels, add nitrogen to eliminate excess oxygen in the tank.
To ensure facility safety, protect personnel, and preserve the integrity of the tanks’ contents while blanketing with nitrogen, employees in facilities utilizing concentration control must maintain proper oxygen levels within storage tanks, as too much oxygen can cause an explosion.

Proper oxygen monitoring equipmentshould be placed inside storage tanks to measure and control oxygen levels.  Oxygen monitors should also be placed in any area where nitrogen is stored or used. Further, the O2 detection equipment should be capable of activating visual and audible alarms and, in the event of a nitrogen leak, stop the flow of nitrogen.

The same property–oxygen displacement –that makes nitrogen blanketing such a valuable process,can be deadly if nitrogen leaks from the supply lines or storage containers. Employees could suffocate from breathing oxygen-deficient air and, since N2 lacks color, and odor, there is no way, absent appropriate monitoring, to determine if there has been a leak.

PureAire Monitors

PureAire Monitoring Systems’ Explosion-Proof Oxygen Deficiency Monitor is perfect for facilities that use inert gases including, but not limited to, nitrogen, helium, and argon. The enclosure is specifically designed to prevent ignition of an explosion. The monitor is well suited for environments such as ethanol refineries, chemical manufactures, corn and grain processing facilities, powder coatingplants, and the oil and gas industry, where combustible materials, dust, and ignitable fibers are present.

The Explosion-Proof Oxygen Monitor’s built-in pump continuously samples oxygen levels from up to 100 feet away, making it ideal for use with storage tanks, confined spaces, and other hard to reach areas where oxygen monitoring is essential.

The monitor constantly measures changes in oxygen levels and can be programmed to control the flow of nitrogen as needed to ensure safe blanketing.  Additionally, should oxygen levels outside the storage tank drop to an OSHA action level,PureAire’s monitor will set off alarms, complete with horns and flashing lights, alerting personnel to evacuate the area.

The monitor will remain accurate at temperatures as low as -40C. PureAire’s durable, non-depleting, zirconium oxide sensor will last up to 10+ years in a normal environment without needing to be replaced.PureAire oxygen monitors measure oxygen 24/7, with no time-consuming maintenance or calibration required.

In short, PureAire’s Explosion-Proof Oxygen Monitor enablesoil, gas, and ethanol refineries, food processors, and other industries blanketing with nitrogen, to preserve, in a cost-effective manner, the well-being of their employees, the integrity of their products and safety of their facilities.

Overview

On January 31, 2020, the Secretary of Health and Human Services (“HHS”) declared a public health emergency related to the COVID-19 pandemic. Shortly thereafter, hand sanitizer began to disappear from U.S. retailers’ shelves, as anxious consumers (and, unfortunately, opportunistic hoarders and resellers as well) swept up all available stock. In the ensuing months, traditional hand sanitizer producers have found it impossible to keep up with the greatly elevated demand for their products, which are now considered indispensable items in efforts to control the pandemic’s spread.

Seeking to address the supply-demand imbalance currently existing within the hand sanitizer industry, the Food and Drug Administration (“FDA”) issued several industry guidance documents in March of this year (with updates later that month and in April) permitting, within specified parameters, entities not previously engaged in sanitizer manufacturing to produce, on a temporary basis (i.e., for the duration of the public health emergency declaredby the HHS Secretary in January of this year) either alcohol-based sanitizers themselves or the ethanol typically used a s a key pharmaceutical ingredient in such sanitizers.

The industry guidance documents (all of which can be found on the FDA’s website and should be read in their entirety) contemplate that such new, albeit temporary, producers of hand sanitizers (or ethanol for hand sanitizers) might include pharmacists/drug compounders and alcohol production firms (that is, distillers of alcoholic spirits for human consumption), as well as certain other businesses capable of meeting the FDA’s stringent conditions regarding hand sanitizer ingredients and manufacturing processes, as well as its registration and product listing requirements.

Since the FDA first issued its industry guidance documents in March, numerous entities and individuals have begun production of hand sanitizers (or ethanol for hand sanitizers) to address the supply gap resulting from the COVID-19 pandemic. New (albeit temporary) industry participants include manufacturing enterprises, licensed pharmacists, and distillers of alcoholic beverages. Reportedly, over 200 American distilleries (which, obviously, have deep experience in working with ethanol) have registered their facilities with the FDA pursuant to the relevant industry guidance documents.

Ethanol(a/k/a Ethyl Alcohol)

Ethanol is a clear, colorless, and (according to most people) relatively pleasant-smelling liquid made from a variety of feedstocks, including grains and crops high in sugar content, such as sorghum, corn, barley, sugar beets, and sugar cane. While it may be best known as the alcohol found in alcoholic beverages, when ethanol has been denatured (that is, made unfit for human consumption by adding certain other chemicals to it, which also make the odor unappealing), it also has many other commercial applications, including as a fuel additive, industrial solvent, key component of cosmetics and personal care items, and as the active pharmaceutical ingredient in certain disinfecting products, including hand sanitizers.

Keeping Safe While Working with Ethanol

Ethanol is highly combustible, with a low flash point, making leaks (including vapor emissions) potentially quite dangerous, and threats from accidental ignition very serious indeed. To detect, and protect against, risks emanating from leaks or excessive concentrations of ethanol, best practices include placing gas detection monitors, containing visual and audible alarms, in areas where ethanol is used or stored.

PureAireMonitors

PureAire Monitoring Systems’Combustible Gas Monitor (LEL) offers continuous readings of ethanol (and can also be programed to detectisopropyl alcohol, ethane, ethylene, and methyl alcohol). The monitor features an easy to read screen, which displays current ethanol levels for at-a-glance observation by employees, who derive peace of mind from the monitor’s presence and reliable performance. In the event of a leak or buildup of gas to an unsafe level, the monitor will set off an alarm, complete with horns and flashing lights, alerting personnel to evacuate the area. At the same time, the monitor can be programmed to turn on the ventilation system.

PureAire’s Combustible GasMonitor (LEL) is housed in a NEMA 4 explosion proof enclosure suitable for Class1, groups B, C, and D.The enclosure is specifically designed to prevent an explosion. The monitor is well suited for facilities that produce alcohol-based hand sanitizers, as well as alcohol distilleries, ethanol refineries, chemical plants, and any location where monitoring is required for combustible gases.

PureAire’s durable, long-life LEL catalytic sensor will last 5-6 years in a normal environment without needing to be replaced.

Sterilizing and Reusing N95 Respirators

Overview
Personal protection equipment (“PPE”)includes the gloves, gowns, N95 respiratory masks, and other items required by doctors, nurses, andother healthcare personnelresponsible for treating patients, including those suffering from infectious diseases.  As has become evident in the current COVID-19 emergency affecting the globe, during a crisis, these critical items may not always be available in the quantities needed to meet the challenge of treating large numbers of sick people.

Among the most sought after PPE items today are N95 respirators. According to the U.S. Food and Drug Administration (“FDA”), N95 respirators are essential gear to protect the wearer from airborne particles and to keep liquid materials from contaminating the wearer’s face. Now, more than ever, there is a need for readily available, sterile N95 respirators.

Challenge/Solution
Thus far, during the COVID-19 pandemic, we have witnessed a desperate struggle by public and private sector entities to keep up with the huge increasein N95 respirator usage which, in turn, has at times left healthcare workers and other front-line personnel without the equipment necessary to safely do their jobs. Traditionally, N95 respirators have been discarded after a single use and, while on-shore production has recently ramped up, demand for the masks far outstrips supply during the present period in which the number of COVID-19 cases surges daily.

Fortunately, as medical providers and first responders scramble to procure the safety products required to attend to the patients in their care, businesses are innovating to meet the significant challenge posed by the current respirator supply/demand mismatch.

For instance, in late March of 2020, Battelle, a Columbus, OH-based nonprofit research and development firm, received FDA approval for its Critical Care Decontamination System (“CCDS”) process for decontaminating, on a very large scale, the N95 face masks used by healthcare providers. The CCDS process involves pumping concentrated hydrogen peroxide vapor (H₂O₂) into so-called decontamination chambers (20-foot shipping containers fitted with racks on which the N95 masks are hung) for a 2 ½ hour decontamination cycle. So long as the masks have not been heavily soiled, the CCDS process will allow each N95 respirator to be sterilized and reused up to 20 times. The system is highly scalable, and Battelle, which intends to deploy CCDS as needed throughout the U.S., believes that its larger versions should be capable of sterilizing up to 80,000 N95 masks per day.

Additionally, in early April, the FDA granted STERIS, another Ohio-based company, an Emergency Use Authorization (“EUA”) to begin, on a temporary basis, small-scale N95 sterilization, pursuant to which certain of the company’s V-PRO Low Temperature Sterilization System machines are approved to sterilize up to 10 masks apiece per 28 minute vaporized hydrogen peroxide sterilization cycle. STERIS reportedly has 100 such V-PRO machines across the State of Ohio which have the capacity to sterilize N95 respirators as provided for in the EUA, and each re-sterilized mask is reusable up to 10 times by repeating the V-PRO process.

Hydrogen Peroxide Vapor
Hydrogen peroxide vapor (“H₂O₂”)is a widely used gaseous sterilant that has been shown to be effective in killing viruses, fungi, bacteria, and other pathogens, and H₂O₂ decontamination is a standard process used in pharmaceutical, research, and medical facilities.H₂O₂ vapor works by breaking apart the outer membranes of the pathogen to which it is applied, thereby destroying thedangerous microorganism.

Hydrogen peroxide is a colorless gas with a sharp odor. Exposure to H₂O₂ can irritate the eyes, nose, throat and skin, as well as cause headaches, dizziness, nausea, and vomiting. Long-term exposure can negatively affect the lungs, producing coughing and shortness of breath, and elevated levels of hydrogen peroxide may result in a build-up of fluid in the lungs (a dangerous condition known as pulmonary edema). The current OSHA permissible exposure limit (PEL) standard is 1 part of hydrogen peroxide parts per million(ppm).

Gas Detection is Crucial for Personnel Safety
Facilities using concentrated hydrogen peroxide vapor to decontaminate PPE or other medical equipment needto ensure that employees are not exposed to H₂O₂ at levels greater than OSHA’s PEL of 1ppm. Since it is always present, the odor from H₂O₂ vapor does not provide warning that hazardous H₂O₂ concentrations may exist. Therefore, in the absence of appropriate monitoring, it is impossible to determine whether hydrogen peroxide concentrations are approaching dangerous levels.

Best practices call for installation of hydrogen peroxide monitors anywhere H₂O₂ is stored or used.

PureAire Monitors

PureAire Monitoring Systems’ Universal Gas Detectors use “smart” sensor cell technology to continuously track levels of ammonia, bromine, hydrogen, hydrogen chloride, and other toxic gases, including hydrogen peroxide. The sensor cell is programmed to monitor for a specific gas and measurement range, as required by the user.

PureAire’s Universal Gas Detectors allow operators of medical decontamination facilities and systems to detect elevated hydrogen peroxide levels before employee health is put at risk. In the event that H₂O₂ is elevated to an unsafe level, the Universal Gas Detector will set off an alarm that includes horns and flashing lights, alerting staff to vacate the affected area.

The Universal Gas Detector’s easy to read screen makes it simple for employees to monitor hydrogen peroxide levels at a glance, providing them with the assurance that their health is not jeopardized while they perform their important work.

Protecting Precious Cargo: Safety Monitoring at IVF and Cryogenic Facilities

Overview

In March 2018, at two separate fertility clinics, one in Clevelandand the other in San Francisco, the cryogenic tanks storing eggs and embryos malfunctioned, resulting in devastating losses for couples hoping to conceive children.

Nationwide, as of December 2019, there were more than 440 sites that store embryos or eggs in specialized storage tanks of liquid nitrogen, but there are no national laws--and few state standards--governing how, or for how long, the reproductive materials contained therein must be stored.

Publicized failures that have caused the destruction of over 4000 patient eggs, embryos, sperm, and reproductive tissue have heightened the awareness of patients, laboratories, and storage entities to the potential risks and liabilities of cryostorage.

In recent years, as certain health plans and insurance companieshave increased coverage offertility treatments, more couples have turned to fertility clinics to improve their chances of starting families.

How Oxygen Monitors Protect IVF and Cryogenic Facilities 

Wherever liquid nitrogen (LN₂) is used, there are risks associated with nitrogen leaks. Nitrogen displaces oxygen, and a leak deprives the air of oxygen, thereby creating a potential health hazard for storage facility staff. When there is not enough oxygen in the air, persons working in the area can become disoriented, lose consciousness,or even suffocate due to the lack of oxygen. Since nitrogen lacks color and odor, there is no way for employees to detect a leak using the senses. Moreover, a nitrogen leak could lead to failure of the cryopreservation tanks storing genetic materials. In order to ensure the safety of employees, and the viability of the materials, in vitro fertilization (IVF) and cryopreservation facilities rely on oxygen monitors.

According to the National Center for Biotechnology Information, facilities using liquid nitrogen should implement a series of quality control steps to monitor LN₂ levels and refill tanks as necessary for proper cryostorage maintenance. Among the recommendations is the installation of oxygen monitors to avert or minimize the effects of potentially serious cryostorage accidents caused by LN₂ leaks.

PureAire Oxygen Monitors

PureAire Monitoring Systems’ oxygen monitors continually sample the air, taking periodic readings of current oxygen levels. PureAire oxygen monitors are ideally suited for use in acryogenic storage facility, because the monitors can withstand temperatures as low as -40C.

In the event of a nitrogen leak, and a decrease in oxygen to a pre-set alarm level, thePureAire monitor’s built-in horn will sound, and lights will begin to flash, thereby providing notification to the facility staff of the possible impending danger to the precious stored materials. The same alert enables employees to take care of their own personal safety, including exiting the area, if necessary.

Best practice calls for oxygen monitors to be placed wherever nitrogen is used or stored.
PureAire Monitoring Systems monitors feature long-lasting zirconium sensors, which are designed to provide accurate readings, without calibration, for up to 10 years. Cryogenic facilities appreciate the ease of use and reliability of PureAire Monitoring Systems products.

Consumers Have No Beef Eating Plant-Based Meats

Overview
How about meat without involving animals? Move over, veggie burgers; food companies such as Beyond Meat and Impossible Foods, among others, have created plant-based meats that smell, taste, and look (imagine a thick, juicy hamburger) like the real thing. Unlike traditional veggie burgers, made from soy and bean paste, which have been marketed primarily to vegetarians, these companies are wooing and winning over a new group of customer-so-called “flexitarians”- consumers who do eat (or, at least, desire the taste and texture of) meat but, for health or sustainability reasons, want to reduce their meat consumption. According to Barclays Investment Bank, roughly one-third of Americans, or 100 million people, follow a flexitarian diet and that number is expected to rise.

Plant-Based Burgers
Impossible Foods, which makes the Impossible Burger, and Beyond Meat, the company responsible for the Beyond Burger, are perhaps the most well-known producers of meats whose ingredients are derived from plants. Although their ingredients and manufacturing processes are not identical, both companies seek to replicate the essential qualities of a hamburger derived from cows: texture (Impossible and Beyond both utilize various plant proteins); fat/marbling (both companies use coconut oil, as well as other cooking oils); coloring (Impossible relies on soy leghemoglobin, or “heme”, while Beyond uses beet and apple extracts); and flavor (both use natural flavors, and the “heme” that Impossible uses for color also enhances the flavor profile of its products.

Growing Availability and Popularity of Plant-Based Meats
For an industry that barely existed five years ago, the plant-based meat sector is experiencing spectacular growth, and over 50,000 grocery stores and restaurants, including Safeway, Whole Foods, Burger King, Subway, White Castle, KFC, and Carl’s Jr., now carry products from Beyond Meat or Impossible Foods.

And burgers are not the only choice when it comes to plant-based meats. Other options include chicken, pork, and sausages. In August of 2019, after a successful trial run in New York City, Dunkin’ Donuts announced it was rolling out a breakfast sandwich made with Beyond Meat sausages in 9,000 of its stores. Likewise, after selling out of the new plant-based Beyond Fried Chicken in Atlanta, KFC is introducing the product at other locations throughout the South.

According to the Good Food Institute, the value of the U.S. plant-based meat market was $801 Million for the year ending April 2019. Furthermore, investment firm UBS projects growth of plant-based protein and meat alternatives to increase from $4.6 billion in 2018 to $85 billion in 2030.

Gas Usage in Facilities Producing Plant-Based Meats
Food safety compliance is critically important in the food industry and, to continue to grow their sales and increase market acceptance, producers must ensure that their plant-based meats are as safe to consume as non-plant-based meats. Safety requirements dictate that plant-based hamburger, sausage, chicken, and other products be rapidly chilled and/or frozen during the production process and before they can be shipped to restaurant or grocery outlets. As such, modern freezing technology, including the use of tunnel freezers, is essential to the ongoing success of the plant-based meat industry.

Tunnel freezers work by rapidly freezing foods using cryogenic gases, such as liquid nitrogen (LN2) or carbon dioxide (CO2). The food items are placed on a conveyor belt, which carries them into the freezer, where an injection system (utilizing either liquid nitrogen or carbon dioxide), together with fans circulating the gas-chilled air, ensures that all food products are quickly and evenly frozen.

Oxygen Monitors Can Improve Safety in Plant-Based Food Manufacturing

While the use of liquid nitrogen and/or carbon dioxide is important in the production of plant-based meats, it is not without risk. LN2 and CO2 are both oxygen depleting gases, and oxygen deprivation could put employees in real danger if there are gas leaks from freezer supply lines or exhaust systems, or from on-site gas storage containers. In the event of a leak, plant personnel could become disoriented, lose consciousness, or even suffocate from breathing oxygen-deficient air. Since LN2 and CO2 are both colorless and odorless, workers would, in the absence of appropriate monitoring, have no way of knowing that there has in fact been a leak. By utilizing a top-quality oxygen monitor, safety and production personnel can track oxygen levels and detect leaks before workers’ health is jeopardized.

PureAire Water-Resistant Dual O2/CO2 Monitors
PureAire Monitoring Systems’ water-resistant dual oxygen/carbon dioxide monitors offer thorough air monitoring, with no time-consuming maintenance or calibration required. A screen displays current oxygen and carbon dioxide levels, for at-a-glance reading by employees, who derive peace of mind from the monitor’s presence and reliable performance. In the event of a nitrogen or carbon dioxide leak, and a decrease in oxygen to an unsafe level, the monitor will set off an alarm, complete with horns and lights, alerting personnel to evacuate the area.

PureAire’s dual oxygen/carbon dioxide monitor is housed in an IP67 water resistant enclosure that will keep the electronics dry during wash-downs, and the monitor will remain accurate at extremely low temperatures. That makes it ideally suited for environments, such as plant-based food processing facilitiesthat use liquid nitrogen and carbon dioxide. Built with zirconium oxide sensor cells and non-dispersive infrared sensor (NDIR) cells to ensure longevity, PureAire’s water-resistant dual O2/CO2 monitors can last, trouble-free, for over 10 years under normal operating conditions.

Cannabis Extraction Safety

In 1996, California passed Proposition 215, making it the first of many states to ultimately legalize medical cannabis; as of January 2020, an additional 32 states and the District of Columbia have also made medical cannabis legal. Additionally, recreational use of cannabis is now legal in 11 states and is decriminalized in many others. Cannabis legalization and decriminalization have made cannabidiol (“CBD”, a non-psychoactive compound found in cannabis), and tetrahydrocannabinol(“THC”, the chemical responsible for most of cannabis' mind-altering effects), available to both recreational users and patients seeking treatment for such health issues as arthritis, anxiety, inflammation, seizure disorders, and nausea.

Since California’s groundbreaking move in 1996, medical and recreational cannabis has become a significant and rapidly growing industry. According to DC-based cannabis researcher, New Frontier Data, legal cannabis sales in the U.S. are expected to reach $30 billion annually by 2025. The industry growth has led to a substantial increase in grow rooms, medical dispensaries and other retail outlets, and extraction facilities.

Extraction
Extraction is a process by which desired chemical compounds are extracted and separated from the cannabis plant. Extraction strips the plant of essential oils, including CBD, THC, and terpenes (aromatic oils that give cannabis plants their distinctive scents). The extracted oils can be utilized in vape pens, edibles, capsules, tinctures, and topical solutions. Based on the end product, various techniques can be used for extracting the oils, including carbon dioxide (CO2) extraction and hydrocarbon solvent extraction (using solvents such as butane or propane).

Carbon Dioxide Extraction
Carbon dioxide, high pressure, and heat can be combined to create a “supercritical fluid” that extracts cannabis components from the plant. The CO2 extraction method generally produces high yields with relatively little waste. Temperatures and pressures can be adjusted to create multiple products including vaporizer oils; dabbing concentrates such as so-called waxes, crumble, shatters, and saps; and distillates (cannabis extracts that have been further purified and processed to separate and isolate the various cannabinoids, which include CBD and THC). Because CO2 evaporates on its own, many in the medical products and food and beverage industries find the CO2 extraction method appealing, since no residual carbon dioxide remains in the final manufactured product.

Hydrocarbon Solvents Extraction
Hydrocarbon extraction typically uses organic solvents such as butane and propane to separate essential oils from the plant material. The use of hydrocarbons for extraction is popular owing, in large part, to the relatively low overhead costs, efficiency (including the wide variety of products that can be created from a single extraction, without the need for further refinement), and high product quality associated with this technique. For instance, the low boiling point of butane, and even lower boiling point of propane, allow extractors to remove the desired compounds without risking evaporation of, or damage to, the delicate and heat-sensitive cannabinoids and terpenes. Moreover, their low boiling points makes it relatively easy to purge any residual butane or propane at the end of the extraction process, leaving behind only a relatively pure product.

Oxygen Monitors Can Protect Extractors and Their Employees
 While CO2 and hydrocarbon solvents are important techniques for extracting essential oils from cannabis plants use of these gases is not without risk, since extraction facility personnel and property are exposed to potential leaks from gas supply lines and storage containers.

Carbon dioxide is an oxygen-depleting gas that is both odorless and colorless. As such, absent appropriate monitoring to detect that a leak has occurred, extraction employees could become dizzy, lose consciousness, and even suffocate from breathing oxygen-deficient air. Hydrocarbons such as butane and propane also deplete oxygen and, they are flammable and explosive as well.

Proper gas detection equipment should be placed where the cannabis extraction process takes place, as well as in CO2 and hydrocarbon storage rooms, and in any other site where CO2, butane, and propane may be expected to accumulate. The gas detection equipment should include the capacity to activate visual and audible alarms, stopping the flow of gas and turning on the ventilation system.

PureAire Monitors

PureAire Monitoring Systems has safety monitors to meet the needs of cannabis extractors, whether they use CO2 or hydrocarbon solvents.

For facilities using carbon dioxide to extract their products, PureAire’s line of dual oxygen/carbon dioxide monitors offer thorough air monitoring, with no time-consuming maintenance or calibration required. The O2/CO2 monitor comes with user-adjustable alarm setpoints for both oxygen and carbon dioxide. The monitor is built with zirconium oxide sensor cells and non-dispersive infrared sensor (NDIR)cells, to ensure longevity.PureAire’s O2/CO2 monitors can last, trouble-free, for over 10 years under normal operating conditions.

Extractors utilizing hydrocarbon solvents, such as butane or propane, rely on PureAire’s LEL, explosion-proof, combustible gas monitors. The monitor is housed in a NEMA 4 enclosure specifically designed to prevent an explosion. The durable, long-life LEL catalytic sensor will last 5+ years without needing to be replaced.

PureAire monitors feature an easy to read screen, which displays current oxygen levels for at-a-glance observation by employees, who derive peace of mind from the monitor’s presence and reliable performance. In the event of a gas leak, or a drop in oxygen to an unsafe OSHA action level, PureAire’s monitors will set off alarms, complete with horns and flashing lights, alerting personnel to evacuate the area. At the same time, the monitors can be programmed to turn off the flow of gas (CO2, butane, or propane, as appropriate), and turn on the ventilation system.

In short, PureAire’s monitors enable cannabis extractors, in a cost-effective manner, to preserve both the quality of their products and the well-being of their employees.